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最權威的專業團隊

首頁 > 關於鑫品 > 最權威的專業團隊


鑫品生醫 研發長 廖順奎教授

專業研究領域:
  • 腫瘤生物及免疫學
  • 免疫細胞治療
  • 樹突狀疫苗
  • 單株抗體之修飾與臨床應用
  • 複合組織移植
  • 癌症試驗治療
  • 間質性幹細胞
  • 癌症幹細胞
學歷:
  • 加拿大多倫多大學 (University of Toronto) 博士後研究員
  • 加拿大 麥可馬斯特大學 (McMaster University) 醫學中心生物醫學博士
  • 東海大學理學院生物系學士
經歷:
  • 台北醫學大學附設醫院 免疫療法中心主任
  • 長庚大學臨床醫學研究所教授
  • 美國紐約瓦爾哈拉紐約醫學院 (New York Medical College, Valhalla, NY, USA) 微生物學與免疫學兼任教授
  • 美國加州霍格癌症中心 (Hoag Cancer Center, Newport Beach, CA, USA) - 腫瘤學實驗室資深特聘研究員
  • 美國富田納西生物治療公司 (Biotherapeutic Inc., Franklin, TN, USA) -免疫生物及單株抗體研發部主任
  • 美國富田納西生物治療研究所 (Biotherapy Institute, Franklin, TN, USA) -學術部主任
  • 加拿大麥可馬斯特大學 (McMaster University, Hamilton, ON, Canada) - 病理學與免疫學助理教授、副教授、教授
  • 加拿大安大略省癌症基金會-漢彌爾頓區域中心 (Ontario Cancer Foundation Hamilton Regional Centre, Hamilton, ON, Canada) - 腫瘤實驗室主任

論文與著作共250篇,下列為代表作:

  1. Huang WC, Lin JY, Wallace CG, Wei HC, Liao SK. Improving the safety of tolerance induction chimerism and cellular cotreatment strategies applied to vacularized composite allografts. Clin Develop Immunol 2012 (doi:10.1155/ 2012/107901)
  2. Lin JY, Tsai FC, Wallace CG, Huang WC, Wei FC, Liao SK. Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning. J Surg Res 2012 Jul 11. [Epub ahead of print]
  3. 廖順奎。調節免疫對抗癌症。科學人 (Scientific American中文版) No. 119 pp. 50-54, 2012, Jauuary issue。
  4. Chow KP N, Lee JM, Liao SK, Lin SC, Lin YF, Wu WH, Qiu JT, Wu TS (2011) Enhanced IL-10 production by CD4+ T cells primed in IL-15Rα-deficient mice. Eur J Immunol 41:3146-56.
  5. Chou AS, Chen HC, Li CR, Hsieh CH, Ting LL, Liao SK.Tumor dormancy resulting from subcutaneous injection to SCID mice with cultured nasopharyngeal carcinoma cells is mediated via IFN-γ induction of a highly differentiated phenotype. Cancer Biother Radiopharm. 2011; 26:417-426.
  6. Chen HC, Chou AS, Liu YC, Hsieh CH, Kang CC, Pang ST, Yeh CT, Liu HP, Liao SK. Induction of metastatic cancer stem cells from the NK/LAK-resistant floating, but not adherent, subset of the UP-LN1 carcinoma cell line by IFN-γ. Lab Invet 2011; 91:1502-1513.
  7. Chuang KL, Pang ST, Liao SK, Wu CT, Chang YH, Chuang HC, Chuang CK. Epstein-Barr virus DNA load in tumour tissues correlates with poor differentiation status in non-muscle invasive urothelial carcinomas.http://www.ncbi.nlm.nih.gov/pubmed/20735392BJU Int 2011; 107:150-154.
  8. Yeh KY, Li YY, Hsieh LL, Lu CH, Chou WC, Liaw CC, Tang RP, Liao SK. Analysis of the effect of serum interleukin-6 (IL-6) and soluble IL-6 receptor levels on survival of patients with colorectal cancer. Jpn J Clin Oncol 2010; 40:580-587.
  9. Chang JW, Hsieh JJ, Shen YC, Ho E, Chuang CK, Chen YR, Liao SK, Chen JS, Leong SP, Hou MM, Chang NJ, Wang CH. Immunotherapy with dendritic cells pulsed by autologous dactinomycin-induced melanoma apoptotic bodies for patients with malignant melanoma. Melanoma Res 2009; 19:305-315.
  10. Chou AS, Wang HY, Chen HC, Tsai MH, Chuang CK, Liao SK. Differential baseline and response profile to IFN-gamma gene transduction of IL-6/IL-6 receptor-alpha secretion discriminate primary tumors versus bone marrow metastases of nasopharyngeal carcinomas in culture. BMC Cancer. 2009; 9:1698.
  11. Hsieh CH, Hsu YJ, Chang CC, Liu HC, Chuang KL, Chuang CK, Pang ST, Hasumi K, Ferrone S, Liao SK. Total HLA class I loss in a sarcomatoid renal carcinoma cell line caused by the coexistence of distinct mutations in the two encoding beta2-microglobulin genes.. Cancer Immunol Immunother 2009; 8: 395-408.  
  12. Chin LT, Chu C, Chen HM, Wang DW, Liao SK. Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J 2008;31:1-15.
  13. Yen CF, Lee CL, Murk W, Han CM, Liao SK. Reducing peritoneal vascular endothelial growth factor concentration and inhibiting cancer scattering in a mouse model of laparoscopy. Am J Obstet Gynecol. 2008; 198:423.e1-7.
  14. Law KS, Chen HC, Liao SK. Non-cytotoxic and sublethal paclitaxel treatment potentiates the sensitivity of cultured ovarian tumor SKOV-3 cells to lysis by lymphokine-activated killer cells. Anticancer Res2007; 272:841-850.
  15. Li KCM, Goodall J, Goding CR, Liao SK, Wang CH, Lin YC, Nojima H, Lee KAW. The melanocyte inducing factor MITF is stably expressed in cell lines from human clear cell sarcoma. Br J Cancer 2005; 89: 1072-1078.
  16. Lin JC, Liao SK, Lee EH, Hung MS, Sayion Y, Chen HC, Kang CC, Huang LS, Cherng J M. Molecular events associated with epithelial to mesenchymal transition of nasopharyngeal carcinoma cells in the absence of Epstein-Barr virus genome. J Biomed Sci 2005; 16:105.
  17. Schaefer KL, Brachwitz K, Wai DH, Braun Y, Diallo R, Korsching E, Eisenacher M, Voss R, van Valen F, Baer C, Selle B, Spahn L, Liao SK, Lee KAW, Poremba C Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3. Cancer Res 2006; 64:3395-3405.
  18. Tsai SL, Lee TH, Chien RN, Liao SK, Lin CL, Kuo GC, Liaw YF.(2004) A method to increase tetramer staining efficiency of CD8+ T cells with MHC-peptide complexes: therapeutic applications in monitoring cytotoxic T lymphocyte activity during hepatitis B and C treatment. J Immunol Meth2004; 285:71-87.
  19. Chuang CK, Liao SK. Epstein-Barr virus infection in urothelial transitional cell carcinoma tissues. BJU Int 2004; 93:495-498.
  20. Ying J, Strivastava G, Hsish W-S, Gao Z, Muarry P, Liao SK, Ambinder R, Tao Q. The stress-responsive gene GADD45γ is a functional tumor suppressor, and its response to environmental stresses is frequently disrupted epigenetically in multiple tumors. Clin Cancer Res 2005; 11:6442-6449.
  21. Chen MF, Keng PC. Wu CT, Mazzatti DJ, Hsu YC, Liao SK. Chen WC. Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression. Int J Radiat Oncol Biol Phys 2006; 64:581-591.
  22. Chen MF, Lin CT, Chen WC, Yang CT, Chen CC, Liao SK, Liu JM, Lu CH, Lee KD. The sensitivity of human mesenchymal stem cells to ionizing radiation.  Am J Obstet Gynecol. 2008; 198:423.e1-7.
  23. Liao SK, Perng YP, Lee LA, Chang KS, Lai GM, Wong E, Ho YS. Newly established MST-1 tumor cell line and tumor-infiltrating lymphocyte culture from a patient with soft tissue melanoma (clear cell sarcoma) and their potential applications to patient immunotherapy. Eur J Cancer1996;32A:346-356.
  24. Oldham RK, Lewis M, Orr W, Liao SK, Ogden JR, Hubbard WH, and Birch R. Individually specified drug immunoconjugates in cancer treatment, Int J Biol Markers 4:65-77.
  25. Liao SK, Meranda C, Avner BP, Romano T, Husseini S, Kimbro B, Oldham RK.   Immunohistochemical phenotyping of human solid tumors with monoclonal antibodies in devising biotherapeutic strategies. Cancer Immunol Immunother 1989; 28:77-86.

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